FKBPL Antikörper

Produktnummer ABIN7252003

Dieses Anti-FKBPL-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von FKBPL in IHC und ELISA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für FKBPL Antikörper (ABIN7252003)

Target: FKBPL (FK506 Binding Protein Like (FKBPL))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FKBPL Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Produktdetails anti-FKBPL Antikörper

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Antigen affinity purification

Immunogen: Fusion protein of human FKBPL

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:30-1:150, ELISA 1:2000-1:10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.3 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu FKBPL

Target: FKBPL (FK506 Binding Protein Like (FKBPL))

Andere Bezeichnung: FKBPL

Hintergrund: FKBPL,also named as DIR1,NG7 and WISp39,has similarity to the immunophilin protein family,which plays a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This protein is thought to have a potential role in the induced radioresistance,probably by increasing the rate of DNA repair in cells exposed to X rays. Also it appears to have some involvement in general stress response in the control of the cell cycle. It regulates p21 protein stability by binding to Hsp90 and p21. Breast cancer cells stably overexpressing FKBPL became dependent on estrogen for their growth and were dramatically more sensitive to the antiestrogens tamoxifen and fulvestrant,whereas FKBPL knockdown reverses this phenotype. FKBPL is an estrogen-inducible gene that acts as a cochaperone in ERα/Hsp90 Molecular complexes, furthermore,FKBPL levels may be both a prognostic indicator and determinant of response to endocrine therapy.

UniProt: Q9UIM3