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SMC1A Antikörper

This anti-SMC1A antibody (ABIN7251964) is a Rabbit Polyclonal antibody detecting SMC1A in WB, IHC, ELISA. Suitable for Human, Mouse, Rat.
Produktnummer ABIN7251964

Quick Overview for SMC1A Antikörper (ABIN7251964)

Target

Alle SMC1A Antikörper anzeigen
SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Reaktivität

  • 135
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Human, Maus, Ratte

Wirt

  • 116
  • 14
  • 4
  • 1
Kaninchen

Klonalität

  • 99
  • 36
Polyklonal

Konjugat

  • 72
  • 7
  • 4
  • 4
  • 4
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  • 4
  • 4
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  • 3
  • 3
  • 2
  • 2
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  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
Dieser SMC1A Antikörper ist unkonjugiert

Applikation

  • 101
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Western Blotting (WB), Immunohistochemistry (IHC), ELISA
  • Produktmerkmale

    Polyclonal Antibody

    Aufreinigung

    Antigen affinity purification

    Immunogen

    Fusion protein of human SMC1A

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    0.5 mg/mL

    Buffer

    PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Avoid freeze / thaw cycles.
  • Target

    SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

    Andere Bezeichnung

    SMC1A

    Hintergrund

    Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

    Molekulargewicht

    Observed_MW: Refer to figures

    Calculated_MW: 143 kDa

    UniProt

    Q14683

    Pathways

    Stem Cell Maintenance
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