Der Maus Monoklonal anti-Active CASP3 Antikörper (Klon 5A2) (ABIN7250272) detektiert spezifisch Active CASP3 in IF, IHC (p) und WB.
Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.
PBS with 0.02 % sodium azide and 50 % glycerol pH 7.4.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Informationen zur Lagerung
Store at -20°C. Avoid freeze / thaw cycles.
Target
Active CASP3
Hintergrund
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.