Der Kaninchen Polyklonal anti-UBE2A Antikörper (ABIN7246475) detektiert spezifisch UBE2A in IHC und ELISA.
Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants.