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IGHA1 Antikörper

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch IGHA1 in IHC und ELISA. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN7246370

Kurzübersicht für IGHA1 Antikörper (ABIN7246370)

Target

IGHA1 (Immunoglobulin Heavy Constant alpha 1 (IGHA1))

Reaktivität

  • 17
  • 2
  • 2
Human

Wirt

  • 14
  • 3
Kaninchen

Klonalität

  • 13
  • 4
Polyklonal

Konjugat

  • 10
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser IGHA1 Antikörper ist unkonjugiert

Applikation

  • 9
  • 7
  • 7
  • 4
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Immunohistochemistry (IHC), ELISA
  • Produktmerkmale

    Polyclonal Antibody

    Aufreinigung

    Antigen affinity purification

    Immunogen

    Fusion protein of human IGHA1

    Isotyp

    IgG
  • Applikationshinweise

    IHC 1:50-1:300, ELISA 1:5000-1:10000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1.14 mg/mL

    Buffer

    PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Avoid freeze / thaw cycles.
  • Target

    IGHA1 (Immunoglobulin Heavy Constant alpha 1 (IGHA1))

    Andere Bezeichnung

    IGHA1

    Hintergrund

    Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).

    UniProt

    P01876
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