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CAMSAP3 Antikörper

CAMSAP3 Reaktivität: Human, Maus ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7245497
  • Target Alle CAMSAP3 Antikörper anzeigen
    CAMSAP3 (Calmodulin Regulated Spectrin-Associated Protein Family, Member 3 (CAMSAP3))
    Reaktivität
    • 21
    • 15
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 21
    Kaninchen
    Klonalität
    • 21
    Polyklonal
    Konjugat
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CAMSAP3 Antikörper ist unkonjugiert
    Applikation
    ELISA, Immunohistochemistry (IHC)
    Produktmerkmale
    Polyclonal Antibody
    Aufreinigung
    Antigen affinity purification
    Immunogen
    Synthetic peptide of human CAMSAP3
    Isotyp
    IgG
    Top Product
    Discover our top product CAMSAP3 Primärantikörper
  • Applikationshinweise
    IHC 1:100-1:300, ELISA 1:5000-1:10000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1.56 mg/mL
    Buffer
    PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    CAMSAP3 (Calmodulin Regulated Spectrin-Associated Protein Family, Member 3 (CAMSAP3))
    Andere Bezeichnung
    CAMSAP3 (CAMSAP3 Produkte)
    Synonyme
    KIAA1543 antikoerper, NEZHA antikoerper, 2310057J16Rik antikoerper, Kiaa1543 antikoerper, Nezha antikoerper, calmodulin regulated spectrin associated protein family member 3 antikoerper, calmodulin regulated spectrin-associated protein family, member 3 antikoerper, CAMSAP3 antikoerper, Camsap3 antikoerper
    Hintergrund
    Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the maintenance of zonula adherens by anchoring the minus-end of microtubules to zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755). Required for orienting the apical-to-basal polarity of microtubules in epithelial cells: acts by tethering non-centrosomal microtubules to the apical cortex, leading to their longitudinal orientation (PubMed:27802168, PubMed:26715742). Plays a key role in early embryos, which lack centrosomes: accumulates at the microtubule bridges that connect pairs of cells and enables the formation of a non-centrosomal microtubule-organizing center that directs intracellular transport in the early embryo (By similarity). Couples non-centrosomal microtubules with actin: interaction with MACF1 at the minus ends of non-centrosomal microtubules, tethers the microtubules to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). Plays a key role in the generation of non-centrosomal microtubules by accumulating in the pericentrosomal region and cooperating with KATNA1 to release non-centrosomal microtubules from the centrosome (PubMed:28386021). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:28089391). Through interaction with AKAP9, involved in translocation of Golgi vesicles in epithelial cells, where microtubules are mainly non-centrosomal (PubMed:28089391).
    UniProt
    Q9P1Y5
    Pathways
    Cell-Cell Junction Organization, Maintenance of Protein Location
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