NPRL2 Antikörper

Produktnummer ABIN7243658

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch NPRL2 in ELISA und IHC. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für NPRL2 Antikörper (ABIN7243658)

Target: NPRL2 (Nitrogen Permease Regulator-Like 2 (S. Cerevisiae) (NPRL2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NPRL2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-NPRL2 Antikörper

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Synthetic peptide of human NPRL2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.9 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu NPRL2

Target: NPRL2 (Nitrogen Permease Regulator-Like 2 (S. Cerevisiae) (NPRL2))

Andere Bezeichnung: NPRL2

Hintergrund: NPRL2, also known as TUSC4 (tumor suppressor candidate 4), is a 380 amino acid protein that contains a bipartite nuclear localization signal and a granulin protein-binding domain. It is highly expressed in skeletal muscle, followed by brain, liver and pancreas, with lower expression in lung, kidney, placenta and heart. NPRL2 is also expressed in most lung cancer cell lines and may be involved in tumor suppression. NPRL2 may play a role in mismatch repair, cell cycle checkpoint signaling and activation of apoptotic pathways. It may also enhance the therapeutic efficacy of chemotherapy drugs such as cis-platin by resensitizing patients resistant to cisplatin treatment. The gene encoding NPRL2 is conserved between species and is expressed as two isoforms due to alternative splicing events.

NCBI Accession: NP_006536

UniProt: Q8WTW4