SMAD7 Antikörper
Kurzübersicht für SMAD7 Antikörper (ABIN7242434)
Target
Alle SMAD7 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Produktmerkmale
- Polyclonal Antibody
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Aufreinigung
- Affinity purification
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Immunogen
- Synthetic peptide of human SMAD7
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Isotyp
- IgG
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Applikationshinweise
- IHC 1:50-1:200
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 0.4 mg/mL
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Buffer
- PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))
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Andere Bezeichnung
- SMAD7
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Hintergrund
- The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
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NCBI Accession
- NP_005895
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UniProt
- O15105
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Pathways
- Interferon-gamma Pathway, Cell-Cell Junction Organization
Target
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