UPF1
Reaktivität: Human
WB, ELISA
Wirt: Maus
Monoclonal
4G3
unconjugated
Applikationshinweise
WB 1:200-1:1000, IHC 1:50-1:200
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konzentration
0.1 mg/mL
Buffer
PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Informationen zur Lagerung
Store at -20°C. Avoid freeze / thaw cycles.
Target
RENT1/UPF1 (UPF1)
(UPF1 Regulator of Nonsense Transcripts Homolog (UPF1))
Andere Bezeichnung
UPF1
Hintergrund
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in botHuman, MouseRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.