Der Kaninchen Polyklonal anti-PKD1 Antikörper (ABIN7238054) detektiert spezifisch PKD1 in ELISA und IHC.
Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.
This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1).