SRGAP3 Antikörper

Produktnummer ABIN7237712

Dieses Anti-SRGAP3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SRGAP3 in ELISA und IHC. Geeignet für Human und Maus.

Kurzübersicht für SRGAP3 Antikörper (ABIN7237712)

Target: SRGAP3 (SLIT-ROBO rho GTPase Activating Protein 3 (SRGAP3))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SRGAP3 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktdetails anti-SRGAP3 Antikörper

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human SRGAP3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:25-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.6 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu SRGAP3

Target: SRGAP3 (SLIT-ROBO rho GTPase Activating Protein 3 (SRGAP3))

Andere Bezeichnung: SRGAP3

Hintergrund: SRGAP3 is a 1099 amino acid protein containing 1 FCH domain, 1 Rho-GAP domain and 1 SH3 domain. Expressed highly in brain, and in lower levels in kidney, WRP is thought to play a role in cell migration through its interaction with Cdc42 and Rac1. Cdc42 and Rac1 are two intracellular signaling proteins that regulate the multistep cell migration process. WRP downregulates Cdc42 and Rac1 activity, thereby impairing actin and microtubule dynamics, the formation of protrusions, and total cell migration. Defects in the gene encoding WRP have been linked to severe idiopathic mental retardation. Three isoforms of WRP exist as a result of alternative splicing events.

UniProt: O43295