Hsp40 (chaperone DnaJ) Antikörper

Produktnummer ABIN7237214

Der Kaninchen Polyklonal anti-Hsp40 (chaperone DnaJ) Antikörper wird verwendet zum Nachweis von Hsp40 (chaperone DnaJ) in Proben von Human, Maus und Ratte. Er wurde validiert für IHC, ELISA und WB.

Kurzübersicht für Hsp40 (chaperone DnaJ) Antikörper (ABIN7237214)

Target: Hsp40 (chaperone DnaJ)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Western Blotting (WB)

Produktdetails

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human DNAJA1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:100-1:300

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Antigendetails

Target: Hsp40 (chaperone DnaJ)

Andere Bezeichnung: HSP40-4

Hintergrund: DnaJ-like proteins interact with HSP 70 Molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen signaling.

Molekulargewicht: 45 kDa

UniProt: P31689