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JAGN1 Antikörper (C-Term)

JAGN1 Reaktivität: Human, Maus, Ratte ELISA, WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6992170
  • Target Alle JAGN1 Antikörper anzeigen
    JAGN1 (Jagunal Homolog 1 (JAGN1))
    Bindungsspezifität
    C-Term
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 5
    Kaninchen
    Klonalität
    • 5
    Polyklonal
    Konjugat
    • 2
    • 1
    • 1
    • 1
    Dieser JAGN1 Antikörper ist unkonjugiert
    Applikation
    • 4
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    JAGN1 antibody is human, mouse and rat reactive. At least four isoforms of JAGN1 are known to exist, this antibody will detect all but isoform 2.
    Aufreinigung
    JAGN1 antibody is affinity chromatography purified via peptide column.
    Immunogen
    JAGN1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human JAGN1. The immunogen is located within the last 50 amino acids of JAGN1.
    Isotyp
    IgG
  • Applikationshinweise
    JAGN1 antibody can be used for detection of JAGN1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL.

    Antibody validated: Western Blot in human samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    JAGN1 antibody is supplied in PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,4 °C
    Informationen zur Lagerung
    JAGN1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
  • Target
    JAGN1 (Jagunal Homolog 1 (JAGN1))
    Andere Bezeichnung
    JAGN1 (JAGN1 Produkte)
    Synonyme
    GL009 antikoerper, 5830427H10Rik antikoerper, zgc:101070 antikoerper, wu:fb07b07 antikoerper, zgc:101045 antikoerper, jagunal homolog 1 antikoerper, jagunal homolog 1 L homeolog antikoerper, jagunal homolog 1a antikoerper, jagunal homolog 1b antikoerper, JAGN1 antikoerper, Jagn1 antikoerper, jagn1.L antikoerper, jagn1a antikoerper, jagn1b antikoerper
    Hintergrund
    JAGN1 is the human ortholog of a gene originally identified in Drosophila melanogaster. It is a transmembrane protein that functions in the early secretory pathway and is necessary for neutrophil differentiation and survival. Individuals with mutations in the JAGN1 gene causes aberrant myeloid cell homeostasis and severe congenital neutropenia (SCN) (1). JAGN1-mutant granulocytes are characterized by ultrastructural defects, aberrant N-glycosylation of multiple proteins, and increased apoptosis (1). Mice lacking this gene could not mount and efficient neutrophil-dependent immune response to a human fungal pathogen (2).
    Molekulargewicht
    Predicted: 20 kDa

    Observed: 25 kDa
    Gen-ID
    84522
    NCBI Accession
    NP_115881
    UniProt
    Q8N5M9
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