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JAGN1 Antikörper (C-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch JAGN1 in ELISA, WB und IHC (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.
Produktnummer ABIN6992170

Kurzübersicht für JAGN1 Antikörper (C-Term) (ABIN6992170)

Target

Alle JAGN1 Antikörper anzeigen
JAGN1 (Jagunal Homolog 1 (JAGN1))

Reaktivität

Human, Maus, Ratte

Wirt

  • 6
Kaninchen

Klonalität

  • 6
Polyklonal

Konjugat

  • 2
  • 2
  • 1
  • 1
Dieser JAGN1 Antikörper ist unkonjugiert

Applikation

  • 5
  • 2
  • 2
  • 2
ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Bindungsspezifität

    C-Term

    Spezifität

    JAGN1 antibody is human, mouse and rat reactive. At least four isoforms of JAGN1 are known to exist, this antibody will detect all but isoform 2.

    Aufreinigung

    JAGN1 antibody is affinity chromatography purified via peptide column.

    Immunogen

    JAGN1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human JAGN1. The immunogen is located within the last 50 amino acids of JAGN1.

    Isotyp

    IgG
  • Applikationshinweise

    JAGN1 antibody can be used for detection of JAGN1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL.

    Antibody validated: Western Blot in human samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    JAGN1 antibody is supplied in PBS containing 0.02 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,4 °C

    Informationen zur Lagerung

    JAGN1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
  • Target

    JAGN1 (Jagunal Homolog 1 (JAGN1))

    Andere Bezeichnung

    JAGN1

    Hintergrund

    JAGN1 is the human ortholog of a gene originally identified in Drosophila melanogaster. It is a transmembrane protein that functions in the early secretory pathway and is necessary for neutrophil differentiation and survival. Individuals with mutations in the JAGN1 gene causes aberrant myeloid cell homeostasis and severe congenital neutropenia (SCN) (1). JAGN1-mutant granulocytes are characterized by ultrastructural defects, aberrant N-glycosylation of multiple proteins, and increased apoptosis (1). Mice lacking this gene could not mount and efficient neutrophil-dependent immune response to a human fungal pathogen (2).

    Molekulargewicht

    Predicted: 20 kDa

    Observed: 25 kDa

    Gen-ID

    84522

    NCBI Accession

    NP_115881

    UniProt

    Q8N5M9
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