IZUMO1 Antikörper (AA 170-220)

Produktnummer ABIN6992154

Der Kaninchen Polyklonal anti-IZUMO1 Antikörper (ABIN6992154) detektiert spezifisch IZUMO1 in ELISA, WB und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für IZUMO1 Antikörper (AA 170-220) (ABIN6992154)

Target: IZUMO1 (Izumo Sperm-Egg Fusion 1 (IZUMO1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IZUMO1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-IZUMO1 Antikörper

Bindungsspezifität: AA 170-220

Spezifität: IZUMO1 antibody is human specific. At least four isoforms of IZUMO1 are known to exist, this antibody will detect the two longest isoforms.

Aufreinigung: IZUMO1 antibody is affinity chromatography purified via peptide column.

Immunogen: IZUMO1 antibody was raised against an 18 amino acid peptide near the center of human IZUMO1. The immunogen is located within amino acids 170 - 220 of IZUMO1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IZUMO1 antibody can be used for detection of IZUMO1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: IZUMO1 antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: IZUMO1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu IZUMO1

Target: IZUMO1 (Izumo Sperm-Egg Fusion 1 (IZUMO1))

Andere Bezeichnung: IZUMO1

Hintergrund: IZUMO1, a sperm-specific protein, is essential for sperm-egg plasma membrane binding and fusion. It is involved in the fertilization process and in the fusion of the sperm with the egg (1,2). IZUMO1 is expressed as at least four isoforms produced by alternative splicing and contains one Ig-like (immunoglobulin-like) C2-type domain (3). Lack of IZUMO1 in males, due to homozygous mutation in the gene that encodes IZUMO1, results in sterility due to an inability to penetrate the plasma membrane of the egg (4).

Molekulargewicht: Predicted: 35, 39, 42 kDa

Observed: 52 kDa

Gen-ID: 284359

NCBI Accession: NP_872381

UniProt: Q8IYV9