Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

DIRAS3 Antikörper (C-Term)

DIRAS3 Reaktivität: Human WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6992120
  • Target Alle DIRAS3 Antikörper anzeigen
    DIRAS3 (DIRAS Family, GTP-Binding RAS-Like 3 (DIRAS3))
    Bindungsspezifität
    • 2
    • 2
    • 1
    • 1
    C-Term
    Reaktivität
    • 22
    • 1
    • 1
    Human
    Wirt
    • 19
    • 3
    Kaninchen
    Klonalität
    • 20
    • 2
    Polyklonal
    Konjugat
    • 10
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser DIRAS3 Antikörper ist unkonjugiert
    Applikation
    • 13
    • 12
    • 8
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Spezifität
    DIRAS3 antibody is human specific.
    Aufreinigung
    DIRAS3 antibody is affinity chromatography purified via peptide column.
    Immunogen
    DIRAS3 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human DIRAS3. The immunogen is located within the last 50 amino acids of DIRAS3.
    Isotyp
    IgG
    Top Product
    Discover our top product DIRAS3 Primärantikörper
  • Applikationshinweise
    DIRAS3 antibody can be used for detection of DIRAS3 by Western blot at 1 - 2 μ,g/mL.

    Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    DIRAS3 antibody is supplied in PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,4 °C
    Informationen zur Lagerung
    DIRAS3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
  • Target
    DIRAS3 (DIRAS Family, GTP-Binding RAS-Like 3 (DIRAS3))
    Andere Bezeichnung
    DIRAS3 (DIRAS3 Produkte)
    Synonyme
    DIRAS3 antikoerper, arhi antikoerper, noey2 antikoerper, ARHI antikoerper, NOEY2 antikoerper, DIRAS family GTPase 3 antikoerper, DIRAS family GTP binding RAS like 3 antikoerper, DIRAS3 antikoerper, diras3 antikoerper
    Hintergrund
    DIRAS3 is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. It is an imprinted gene, with mono-allelic expression of the paternal allele, which is associated with growth suppression and down-regulation of cyclin D1 promoter activity and induction of p21 (WAF/CIP1). Thus, this gene appears to be a putative tumor suppressor gene whose function is abrogated in ovarian and breast cancers (1). DIRAS3 has been shown to induce autophagy in human ovarian cancer cells by blocking PI3K signaling, inhibiting the mammalian target of rapamycin (TOR), upregulating ATG4, and colocalizing with LC3 in autophagosomes (2). DIRAS also interacts with C-RAF and downregulates mitogen-activated protein kinase kinases (MEK) to restrict cell migration (3).
    Molekulargewicht
    Predicted: 25 kDa

    Observed: 24 kDa
    Gen-ID
    9077
    NCBI Accession
    NP_004666
    UniProt
    O95661
Sie sind hier:
Kundenservice