ADRM1 Antikörper (AA 210-260)

Produktnummer ABIN6992113

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ADRM1 in WB, ELISA und IHC (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für ADRM1 Antikörper (AA 210-260) (ABIN6992113)

Target: ADRM1 (Adrm1) (Adhesion Regulating Molecule 1 (Adrm1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADRM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-ADRM1 Antikörper

Bindungsspezifität: AA 210-260

Spezifität: ADRM1 antibody is human, mouse and rat reactive. At least two isoforms of ADRM1 are know to exist, this antibody will detect both isoforms.

Aufreinigung: ADRM1 antibody is affinity chromatography purified via peptide column.

Immunogen: ADRM1 antibody was raised against a 19 amino acid peptide near the center of human ADRM1. The immunogen is located within amino acids 210 - 260 of ADRM1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ADRM1 antibody can be used for detection of ADRM1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: ADRM1 antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: ADRM1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu ADRM1

Target: ADRM1 (Adrm1) (Adhesion Regulating Molecule 1 (Adrm1))

Andere Bezeichnung: ADRM1

Hintergrund: The adhesion-regulating molecule 1 (ADRM1) is thought to be involved in protein recruitment and cell adhesion and functions as a proteasomal ubiquitin receptor (1). ADRM1 promotes the activity of UCH-L5 and plays a role in lymphocyte homing. The carboxy-terminal domain of mammalian ADRM1 serves to bind and enhance the isopeptidase activity of UCHL5/UCH37, perhaps serving as a mechanism to accelerate ubiquitin chain disassembly (2,3). ADRM1 expression is induced by IFN-gamma in some cancer cell lines and its expression is upregulated in other metastatic cells, suggesting a role in carcinogenesis (4,5).

Molekulargewicht: Predicted: 45 kDa

Observed: 48 kDa

Gen-ID: 11047

NCBI Accession: NP_783163

UniProt: Q16186

Pathways: Positive Regulation of Endopeptidase Activity