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Deltex Homolog 4 Antikörper (AA 230-280)

Dieses Anti-Deltex Homolog 4-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Deltex Homolog 4 in ELISA, WB, IF und IHC (p). Geeignet für Human und Maus.
Produktnummer ABIN6992091

Kurzübersicht für Deltex Homolog 4 Antikörper (AA 230-280) (ABIN6992091)

Target

Alle Deltex Homolog 4 (DTX4) Antikörper anzeigen
Deltex Homolog 4 (DTX4) (Deltex Homolog 4 (Drosophila) (DTX4))

Reaktivität

  • 20
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 1
  • 1
Human, Maus

Wirt

  • 20
Kaninchen

Klonalität

  • 20
Polyklonal

Konjugat

  • 10
  • 3
  • 3
  • 2
  • 1
  • 1
Dieser Deltex Homolog 4 Antikörper ist unkonjugiert

Applikation

  • 15
  • 13
  • 4
  • 3
  • 2
  • 2
  • 1
ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Bindungsspezifität

    • 10
    • 5
    • 3
    • 3
    • 1
    • 1
    AA 230-280

    Spezifität

    DTX4 antibody is human and mouse reactive. At least two isoforms of DTX4 are known to exist, this antibody will detect both isoforms. DTX4 antibody is predicted to not cross-react with other DTX protein family members.

    Aufreinigung

    DTX4 antibody is affinity chromatography purified via peptide column.

    Immunogen

    DTX4 antibody was raised against a 19 amino acid peptide near the center of human DTX4. The immunogen is located within amino acids 230 - 280 of DTX4.

    Isotyp

    IgG
  • Applikationshinweise

    DTX4 antibody can be used for detection of DTX4 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    DTX4 antibody is supplied in PBS containing 0.02 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,4 °C

    Informationen zur Lagerung

    DTX4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
  • Target

    Deltex Homolog 4 (DTX4) (Deltex Homolog 4 (Drosophila) (DTX4))

    Andere Bezeichnung

    DTX4

    Hintergrund

    The Deltex 4 E3 ubiquitin ligase (DTX4) is a member of a protein family that is involved in Notch signaling and neurogenesis (1). Recent studies have shown that DTX4 is also associated with the innate immune response (2). Following the activation of type I interferon signaling, the Nod-like receptor protein 4 (NLRP4) recruits DTX4 for Lys48-linked polyubiquitination and degradation of the kinase TBK1 (NAK), thereby maintaining immune homeostasis during antiviral innate immunity (2).

    Molekulargewicht

    Predicted: 68 kDa

    Observed: 68 kDa

    Gen-ID

    23220

    NCBI Accession

    NP_055992

    UniProt

    Q9Y2E6

    Pathways

    Notch Signalweg
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