UVRAG Antikörper (C-Term)

Produktnummer ABIN6992055

Produktdetails anti-UVRAG Antikörper

Target: UVRAG (UV Radiation Resistance Associated Gene (UVRAG))

Bindungsspezifität: AA 490-540, C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UVRAG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: UVRAG antibody is human and mouse reactive.

Aufreinigung: UVRAG antibody is affinity chromatography purified via peptide column.

Immunogen: UVRAG antibody was raised against an 18 amino acid peptide near the carboxy terminus of human UVRAG. The immunogen is located within amino acids 490 - 540 of UVRAG.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: UVRAG antibody can be used for detection of UVRAG by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: UVRAG antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: UVRAG antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu UVRAG

Target: UVRAG (UV Radiation Resistance Associated Gene (UVRAG))

Andere Bezeichnung: UVRAG (UVRAG Produkte)

Synonyme: DHTX antikoerper, VPS38 antikoerper, p63 antikoerper, 9530039D02Rik antikoerper, AI648770 antikoerper, BB124205 antikoerper, Uvrag1 antikoerper, Uvragl antikoerper, zgc:56164 antikoerper, uvrag antikoerper, MGC81810 antikoerper, UVRAG antikoerper, MGC131135 antikoerper, CG6116 antikoerper, Dmel\\CG6116 antikoerper, UV radiation resistance associated antikoerper, UV radiation resistance associated gene antikoerper, UV radiation resistance associated S homeolog antikoerper, UV radiation resistance associated L homeolog antikoerper, UV-resistance associated gene antikoerper, UVRAG antikoerper, Uvrag antikoerper, uvrag antikoerper, uvrag.S antikoerper, uvrag.L antikoerper

Hintergrund: The class III type phosphoinositide 3-kinase (PI3KC3) / Vps34 regulates vacuolar trafficking as well as autophagy (1). UVRAG (UV radiation resistance-associated gene) is associated with the Beclin-1/PI3KC3 complex and promotes PI3KC3 enzymatic activity and autophagy, while suppressing proliferation (2). UVRAG is highly expressed in brain, lung, kidney and liver and contains one C2 domain, which is involved in calcium-dependent phospholipid binding. Beclin-1 binding to UVRAG promotes both autophagosome maturation and endocytic trafficking (3). UVRAG is also a potential tumor suppressor protein with frameshift mutations observed in colon and gastric carcinomas (4,5).

Molekulargewicht: Predicted: 77 kDa

Observed: 75 kDa

Gen-ID: 7405

NCBI Accession: NP_003360

UniProt: Q9P2Y5