SNCA Antikörper (C-Term)

Produktnummer ABIN6992039

Der Kaninchen Polyklonal Anti-SNCA-Antikörper wurde für WB, ELISA, IF und IHC (p) validiert. Er ist geeignet, SNCA in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für SNCA Antikörper (C-Term) (ABIN6992039)

Target: SNCA (Synuclein, alpha (SNCA))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SNCA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-SNCA Antikörper

Bindungsspezifität: C-Term

Spezifität: SNCA antibody is human, mouse and rat reactive. At least three isoforms of SNCA are known to exist.

Aufreinigung: SNCA antibody is affinity chromatography purified via peptide column.

Immunogen: SNCA antibody was raised against a 19 amino acid peptide near the carboxy terminus of human SNCA. The immunogen is located within the last 50 amino acids of SNCA.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: SNCA antibody can be used for detection of SNCA by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human and mouse samples, Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: SNCA antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Details zu SNCA

Target: SNCA (Synuclein, alpha (SNCA))

Andere Bezeichnung: SNCA

Hintergrund: Alpha-Synuclein (SNCA) is a hallmark of Alzheimer's disease (1,2). It is a cytoplasmic protein that is predominantly expressed in the central nervous system (2). SNCA reduces neuronal responsiveness to various apoptotic stimuli, leading to the decreased caspase-3 activation. SNCA may be involved in the regulation of dopamine release and transport and induces fibrillization of microtubule-associated protein tau (3). Defects in SNCA are associated with familial Parkinson's disease (4,5).

Molekulargewicht: Predicted: 12 kDa

Observed: 16 kDa

Gen-ID: 6622

NCBI Accession: NP_000336

UniProt: P37840

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity