OASL Antikörper (N-Term)

Produktnummer ABIN6991998

Dieses Anti-OASL-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von OASL in WB, ELISA, ICC und IF. Geeignet für Human, Maus und Ratte.

Kurzübersicht für OASL Antikörper (N-Term) (ABIN6991998)

Target: OASL (2'-5'-Oligoadenylate Synthetase-Like (OASL))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OASL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Produktdetails anti-OASL Antikörper

Bindungsspezifität: N-Term

Spezifität: OASL antibody is human, mouse and rat reactive.

Aufreinigung: OASL antibody is affinity chromatography purified via peptide column.

Immunogen: OASL antibody was raised against a 17 amino acid peptide near the amino terminus of human OASL. The immunogen is located within the first 50 amino acids of OASL.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: OASL antibody can be used for detection of OASL by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunocytochemistry at 2.5 μ,g/mL. For Immunoflorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: OASL Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: OASL antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu OASL

Target: OASL (2'-5'-Oligoadenylate Synthetase-Like (OASL))

Andere Bezeichnung: OASL

Hintergrund: OASL (2'-5'-oligoadenylate synthetase-like), also known as p59OASL or TRIP14 (thyroid receptor-interacting protein 14), is a 514 amino acid protein that exists as two alternatively spliced isoforms, designated p56 and p30, and contains two ubiquitin-like domains (1). It is widely expressed in a variety of tissues and interacts with the ligand binding domain of the thyroid receptor (TR) and is able to bind double-stranded RNA and DNA, possibly playing a role in RNA degradation and the overall inhibition of protein synthesis (2-3). Methyl CpG-binding protein 1 (MBD1), which functions as a transcriptional repressor, was identified as a strong p59 OASL interactor (4).

Molekulargewicht: Predicted: 57 kDa

Observed: 65 kDa

Gen-ID: 8638

NCBI Accession: NP_003724

UniProt: Q15646