Der Kaninchen Polyklonal Anti-GLIPR1-Antikörper wurde für ELISA, WB und IF validiert. Er ist geeignet, GLIPR1 in Proben von Human und Maus zu detektieren.
GLIPR1 antibody is human and mouse reactive. At least two isoforms of GLIPR1 are known to exist, this antibody will detect both isoforms. This antibody is predicted to not cross-react with other GLIPR or GLIPR-like proteins.
Aufreinigung
GLIPR1 antibody is affinity chromatography purified via peptide column.
Immunogen
GLIPR1 antibody was raised against an 18 amino acid peptide near the center of human GLIPR1. The immunogen is located within amino acids 60 - 110 of GLIPR1.
GLIPR1 antibody can be used for detection of GLIPR1 by Western blot at 1 - 2 μ,g/mL. For Immunoflorescence start at 5 μ,g/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konzentration
1 mg/mL
Buffer
GLIPR1 antibody is supplied in PBS containing 0.02 % sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C,4 °C
Informationen zur Lagerung
GLIPR1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Target
GLIPR1
(GLI Pathogenesis-Related 1 (GLIPR1))
Andere Bezeichnung
GLIPR1
Hintergrund
The glioma pathogensis-related protein 1 (GLIPR1) is similar to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family (1). GLIPR1 is a tumor suppressor whose expression is regulated by p53, its increased expression is associated with myelomocytic differentiation in macrophages, whereas decreased expression of this gene through gene methylation is associated with prostate cancer (2). The GLIPR1 gene is part of a p53 target gene cluster that includes GLIPR1L1 and GLIPR1L2, two highly homologous proteins whose expression patterns vary (3).