AIMP2 Antikörper (AA 150-200)

Produktnummer ABIN6991920

Der Kaninchen Polyklonal anti-AIMP2 Antikörper (ABIN6991920) detektiert spezifisch AIMP2 in WB, ELISA, IF und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für AIMP2 Antikörper (AA 150-200) (ABIN6991920)

Target: AIMP2 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 2 (AIMP2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AIMP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-AIMP2 Antikörper

Bindungsspezifität: AA 150-200

Spezifität: AIMP2 antibody is human specific. AIMP2 antibody is predicted to not cross-react with AIMP1.

Aufreinigung: AIMP2 antibody is affinity chromatography purified via peptide column.

Immunogen: AIMP2 antibody was raised against a 16 amino acid peptide near the center of human AIMP2. The immunogen is located within amino acids 150 - 200 of AIMP2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: AIMP2 antibody can be used for detection of AIMP2 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: AIMP2 antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: AIMP2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu AIMP2

Target: AIMP2 (Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 2 (AIMP2))

Andere Bezeichnung: AIMP2

Hintergrund: AIMP2 was initially identified as a part of an aminoacyl-tRNA synthesase complex (1). It was later discovered to be a cofactor and substrate of Parkin, a Ring-type E3 ubiquitin ligase that is important for the survival of dopamine neurons in Parkinson's disease, accumulation of AIMP2 in these cells lead to catecholaminergic cell death (2). AIMP2 can also bind to TRAF2, a key player in the TNF-alpha signaling pathway, causing the ubiquitination of TRAF2 by cIAP1, leading to TNF-alpha-dependent apoptosis (3). Finally, AIMP2 has been suggested to function as a tumor suppressor (4).

Molekulargewicht: Predicted: 35 kDa

Observed: 36 kDa

Gen-ID: 7965

NCBI Accession: NP_006294

UniProt: Q13155