FLI1 Antikörper (C-Term)

Produktnummer ABIN6991893

Dieses Anti-FLI1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von FLI1 in WB, ELISA und IF. Geeignet für Human, Maus und Ratte.

Kurzübersicht für FLI1 Antikörper (C-Term) (ABIN6991893)

Target: FLI1 (Friend Leukemia Virus Integration 1 (FLI1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FLI1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-FLI1 Antikörper

Bindungsspezifität: C-Term

Spezifität: FLI1 antibody is human, mouse and rat reactive. At least four isoforms of FLI1 are known to exist, this antibody will detect all four.

Aufreinigung: FLI1 Antibody is affinity chromatography purified via peptide column.

Immunogen: FLI1 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human FLI1. The immunogen is located within the last 50 amino acids of FLI1 .

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FLI1 antibody can be used for detection of FLI1 by Western blot at 0.5 - 1 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: FLI1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: FLI1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu FLI1

Target: FLI1 (Friend Leukemia Virus Integration 1 (FLI1))

Andere Bezeichnung: FLI1

Hintergrund: The Friend leukemia virus integration 1 (FLI1) protein is a transcription factor containing an ETS DNA-binding domain and is highly expressed in hematopoietic cell lineages and vascular endothelial cells (1). FLI1 plays important roles in megakaryocytic differentiation (2) and vascular homeostasis (3). The FLI1 gene can undergo a t(11,22)(q24,q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. (4). Abnormal expression of FLI1 can be used as an adverse prognostic indicator for acute myeloid leukemia (5).

Molekulargewicht: Predicted: 50 kDa

Observed: 52kDa

Gen-ID: 2313

NCBI Accession: NP_002008

UniProt: Q01543