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BimEL Antikörper (N-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch BimEL in WB, ELISA, ICC und IF. Er zeigt eine Reaktivität gegenüber Ratte, Human und Maus.
Produktnummer ABIN6991882

Kurzübersicht für BimEL Antikörper (N-Term) (ABIN6991882)

Target

BimEL

Reaktivität

Ratte, Human, Maus

Wirt

  • 2
Kaninchen

Klonalität

  • 2
Polyklonal

Konjugat

  • 2
Dieser BimEL Antikörper ist unkonjugiert

Applikation

Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
  • Bindungsspezifität

    AA 20-70, N-Term

    Spezifität

    Bim EL antibody is human and mouse reactive. Multiple isoforms of Bim are known to exist, this antibody only detects the Bim EL isoform.

    Aufreinigung

    Bim EL Antibody is affinity chromatography purified via peptide column.

    Immunogen

    Bim EL antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of human Bim. The immunogen is located within amino acids 20 - 70 of Bim EL.

    Isotyp

    IgG
  • Applikationshinweise

    Bim EL antibody can be used for detection of Bim EL by Western blot at 1 - 2 μ,g/mL.

    Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    Bim EL Antibody is supplied in PBS containing 0.02 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,4 °C

    Informationen zur Lagerung

    Bim EL antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
  • Target

    BimEL

    Andere Bezeichnung

    Bim EL

    Hintergrund

    Bim EL Antibody: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. Bim, also known as Bcl-2-like protein 11, is a pro-apoptotic member of this family and interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. Multiple isoforms of Bim are known to exist, with Bim EL being the longest isoform (1,2).

    Molekulargewicht

    Predicted: 22 kDa

    Observed: 24 kDa

    Gen-ID

    10018

    NCBI Accession

    NP_619527

    UniProt

    O43521
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