DAP Antikörper (C-Term)

Produktnummer ABIN6991874

Der Kaninchen Polyklonal anti-DAP Antikörper wird verwendet zum Nachweis von DAP in Proben von Human, Ratte und Maus. Er wurde validiert für ELISA, WB, IF und IHC (p).

Kurzübersicht für DAP Antikörper (C-Term) (ABIN6991874)

Target: DAP (Death-Associated Protein (DAP))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DAP Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-DAP Antikörper

Bindungsspezifität: C-Term

Spezifität: DAP antibody is human, mouse and rat reactive.

Aufreinigung: DAP Antibody is affinity chromatography purified via peptide column.

Immunogen: DAP antibody was raised against a 19 amino acid peptide near the carboxy terminus of human DAP. The immunogen is located within the last 50 amino acids of DAP.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: DAP antibody can be used for detection of DAP by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: DAP Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: DAP antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu DAP

Target: DAP (Death-Associated Protein (DAP))

Andere Bezeichnung: DAP

Hintergrund: DAP Antibody: The Death-associated protein (DAP) is a basic proline-rich 15 kDa protein that as a positive mediator of programmed cell death that is induced by interferon-gamma (1). DAP is also a direct substrate of mammalian target of rapamycin (mTOR), a serine/threonine kinase that regulates cell growth and cell cycle, and a negative regulator of autophagy. Under rich nutrient conditions, mTOR phosphorylates DAP at Ser3 and Ser51, under starvation conditions, these residues are dephosphorylated and DAP is converted into an active suppressor of autophagy (2).

Molekulargewicht: Predicted: 11 kDa

Observed: 11 kDa

Gen-ID: 1611

NCBI Accession: NP_004385

UniProt: P51397

Pathways: Positive Regulation of Endopeptidase Activity, Feeding Behaviour