RNF20 Antikörper (N-Term)

Produktnummer ABIN6991864

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch RNF20 in WB, ELISA, IF und IHC (p). Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für RNF20 Antikörper (N-Term) (ABIN6991864)

Target: RNF20 (Ring Finger Protein 20 (RNF20))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RNF20 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-RNF20 Antikörper

Bindungsspezifität: AA 130-180, N-Term

Spezifität: Multiple isoforms of RNF20 are known to exist.

Aufreinigung: RNF20 Antibody is affinity chromatography purified via peptide column.

Immunogen: RNF20 antibody was raised against a 19 amino acid peptide near the amino terminus of human RNF20. The immunogen is located within amino acids 130 - 180 of RNF20.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: RNF20 antibody can be used for detection of RNF20 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: RNF20 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: RNF20 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu RNF20

Target: RNF20 (Ring Finger Protein 20 (RNF20))

Andere Bezeichnung: RNF20

Hintergrund: RNF20 Antibody: RNF20 is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. RNF20 selectively suppresses the expression of some genes such as several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS). In contrast, RNF20 also positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. Together with the deubiquitinase USP44, RNF20 regulates stem cell differentiation by modulating H2B monoubiquitination.

Molekulargewicht: Predicted: 99, 107 kDa

Observed: 100, 110 kDa

Gen-ID: 56254

NCBI Accession: NP_062538

UniProt: Q5VTR2