DIS3 Antikörper (N-Term)

Produktnummer ABIN6991861

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch DIS3 in WB, ELISA, IF und IHC (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für DIS3 Antikörper (N-Term) (ABIN6991861)

Target: DIS3 (Exosome Complex Exonuclease RRP44 (DIS3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DIS3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-DIS3 Antikörper

Bindungsspezifität: AA 90-140, N-Term

Spezifität: Multiple isoforms of DIS3 are known to exist.

Aufreinigung: DIS3 Antibody is affinity chromatography purified via peptide column.

Immunogen: DIS3 antibody was raised against an 18 amino acid peptide near the amino terminus of human DIS3. The immunogen is located within amino acids 90 - 140 of DIS3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: DIS3 antibody can be used for detection of DIS3 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: DIS3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: DIS3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu DIS3

Target: DIS3 (Exosome Complex Exonuclease RRP44 (DIS3))

Andere Bezeichnung: DIS3

Hintergrund: DIS3 Antibody: The exosome is involved in a multitude of cellular RNA processing and degradation events. DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species. DIS3 localizes to both the cytoplasm and the nucleus and contains one PINc domain. It is widely expressed with highest expression in testis and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis.

Molekulargewicht: Predicted: 105 kDa

Observed: 103 kDa

Gen-ID: 22894

NCBI Accession: NP_055768

UniProt: Q9Y2L1