CRTC2 Antikörper (C-Term)

Produktnummer ABIN6991855

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CRTC2 in WB, ELISA, IF und IHC (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für CRTC2 Antikörper (C-Term) (ABIN6991855)

Target: CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CRTC2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-CRTC2 Antikörper

Bindungsspezifität: C-Term

Spezifität: Multiple isoforms of CRTC2 are known to exist. CRTC2 antibody is predicted to not cross-react with CRTC1.

Aufreinigung: CRTC2 Antibody is affinity chromatography purified via peptide column.

Immunogen: CRTC2 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human CRTC2. The immunogen is located within the last 50 amino acids of CRTC2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: CRTC2 antibody can be used for detection of CRTC2 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: CRTC2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: CRTC2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu CRTC2

Target: CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))

Andere Bezeichnung: CRTC2

Hintergrund: CRTC2 Antibody: CRTC2, also known as TORC2 (Transducers Of Regulated cAMP Response Element-Binding (CREB)) 2 and the related protein CRTC1 are potent CREB coactivators that are exported from the nucleus in a CRM1-dependent manner via phosphorylation-dependent interactions. Studies suggest that their phosphorylation and nuclear/cytoplasmic shuttling play an important role in the regulation of gluconeogenesis by cAMP. CRTC2 is present in both B and T-lymphocytes and abundantly expressed in the thymus. Its activity is important in regulating the expression of genes involved in cellular energy metabolism while CRTC1 is essential for energy balance and fertility.

Molekulargewicht: Predicted: 67, 76 kDa

Observed: 70 kDa

Gen-ID: 200186

NCBI Accession: NP_859066

UniProt: Q53ET0

Pathways: AMPK Signaling, Carbohydrate Homeostasis