SHISA4 Antikörper (AA 100-150)

Produktnummer ABIN6991838

Der Kaninchen Polyklonal anti-SHISA4 Antikörper wird verwendet zum Nachweis von SHISA4 in Proben von Human und Maus. Er wurde validiert für WB, ELISA, IF und IHC (p).

Kurzübersicht für SHISA4 Antikörper (AA 100-150) (ABIN6991838)

Target: SHISA4 (Shisa Homolog 4 (SHISA4))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SHISA4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-SHISA4 Antikörper

Bindungsspezifität: AA 100-150

Spezifität: SHISA4 antibody is predicted to not cross-react with other SHISA protein family members.

Aufreinigung: SHISA4 Antibody is affinity chromatography purified via peptide column.

Immunogen: SHISA4 antibody was raised against a 15 amino acid peptide near the center of human SHISA4 . The immunogen is located within amino acids 100 - 150 of SHISA4.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: SHISA4 Antibody can be used for detection of SHISA4 by Western blot starting at 1 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: SHISA4 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: SHISA4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu SHISA4

Target: SHISA4 (Shisa Homolog 4 (SHISA4))

Andere Bezeichnung: SHISA4

Hintergrund: SHISA4 Antibody: SHISA4 plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. The Shisa family of single-transmembrane proteins is characterized by an N-terminal cysteine-rich domain and a proline-rich C-terminal region. Its founding member, Xenopus Shisa, promotes head development by antagonizing Wnt and FGF signaling. Shisa physically interacted with immature forms of the Wnt receptor Frizzled and the FGF receptor within the ER and inhibited their posttranslational maturation and trafficking to the cell surface. Loss of Shisa function sensitized the neuroectoderm to Wnt signaling and suppressed head formation during gastrulation.

Molekulargewicht: Predicted: 22 kDa

Observed: 24 kDa

Gen-ID: 149345

NCBI Accession: NP_937792

UniProt: Q96DD7