SHISA3 Antikörper (AA 120-170)

Produktnummer ABIN6991837

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SHISA3 in WB, ELISA, IHC (p) und IF. Er zeigt eine Reaktivität gegenüber Maus, Human und Ratte.

Kurzübersicht für SHISA3 Antikörper (AA 120-170) (ABIN6991837)

Target: SHISA3 (Shisa Homolog 3 (SHISA3))

Reaktivität: Maus, Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SHISA3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Produktdetails anti-SHISA3 Antikörper

Bindungsspezifität: AA 120-170

Spezifität: SHISA3 antibody is predicted to not cross-react with other SHISA protein family members.

Aufreinigung: SHISA3 Antibody is affinity chromatography purified via peptide column.

Immunogen: SHISA3 antibody was raised against a 15 amino acid peptide near the center of human SHISA3 . The immunogen is located within amino acids 120 - 170 of SHISA3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: SHISA3 Antibody can be used for detection of SHISA3 by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: SHISA3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: SHISA3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu SHISA3

Target: SHISA3 (Shisa Homolog 3 (SHISA3))

Andere Bezeichnung: SHISA3

Hintergrund: SHISA3 Antibody: SHISA3 plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. The Shisa family of single-transmembrane proteins is characterized by an N-terminal cysteine-rich domain and a proline-rich C-terminal region. Its founding member, Xenopus Shisa, promotes head development by antagonizing Wnt and FGF signaling. Shisa physically interacted with immature forms of the Wnt receptor Frizzled and the FGF receptor within the ER and inhibited their posttranslational maturation and trafficking to the cell surface. Loss of Shisa function sensitized the neuroectoderm to Wnt signaling and suppressed head formation during gastrulation.

Molekulargewicht: Predicted: 26 kDa

Observed: 28 kDa

Gen-ID: 152573

NCBI Accession: NP_001073974

UniProt: A0PJX4