CARM1 Antikörper (N-Term)

Produktnummer ABIN6991814

Der Kaninchen Polyklonal Anti-CARM1-Antikörper wurde für WB, ELISA und IF validiert. Er ist geeignet, CARM1 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für CARM1 Antikörper (N-Term) (ABIN6991814)

Target: CARM1 (Coactivator-Associated Arginine Methyltransferase 1 (CARM1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CARM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-CARM1 Antikörper

Bindungsspezifität: AA 470-520, N-Term

Aufreinigung: CARM1 Antibody is affinity chromatography purified via peptide column.

Immunogen: Rabbit polyclonal CARM1 antibody was raised against a 19 amino acid peptide near the amino terminus of human CARM1. The immunogen is located within amino acids 470 - 520 of CARM1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: CARM1 antibody can be used for detection of CARM1 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: CARM1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: CARM1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu CARM1

Target: CARM1 (Coactivator-Associated Arginine Methyltransferase 1 (CARM1))

Andere Bezeichnung: CARM1

Hintergrund: CARM1 Antibody: Protein arginine N-methyltransferases, such as CARM1, catalyze the transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine. Protein arginine methylation has been implicated in signal transduction, metabolism of nascent pre-RNA, and transcriptional activation. CARM1 functions as a transcriptional co-activator for various nuclear receptors and NF-κ,B. It has also been shown to methylate histone H3 arginines, inhibiting the binding of corepressors and protecting chromatin from deacetylation, thereby facilitating transcription.

Molekulargewicht: Predicted: 67 kDa

Gen-ID: 10498

NCBI Accession: NP_954592

UniProt: Q86X55

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Positive Regulation of fat Cell Differentiation