CRB2 Antikörper (AA 460-510)

Produktnummer ABIN6991796

Der Kaninchen Polyklonal Anti-CRB2-Antikörper wurde für ELISA und WB validiert. Er ist geeignet, CRB2 in Proben von Human und Maus zu detektieren.

Kurzübersicht für CRB2 Antikörper (AA 460-510) (ABIN6991796)

Target: CRB2 (Crumbs Homolog 2 (CRB2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CRB2 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Produktdetails anti-CRB2 Antikörper

Bindungsspezifität: AA 460-510

Spezifität: At least three isoforms of CRB2 are known to exist, this antibody will detect all three. CRB2 antibody is predicted to not cross-react with other members of the CRB family.

Aufreinigung: CRB2 Antibody is affinity chromatography purified via peptide column.

Immunogen: Rabbit polyclonal CRB2 antibody was raised against a 17 amino acid peptide near the center of human CRB2. The immunogen is located within amino acids 460 - 510 of CRB2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: CRB2 antibody can be used for detection of CRB2 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: CRB2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: CRB2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu CRB2

Target: CRB2 (Crumbs Homolog 2 (CRB2))

Andere Bezeichnung: CRB2

Hintergrund: CRB2 Antibody: CRB2 (Crumbs homolog 2), like its homologs CRB1 and CRB3, is similar to the Drosophila crumbs protein and is expressed in retina, brain and kidney. Along with other proteins, the Crumbs proteins form a complex that help set up cell polarity in developing neuroepithelial cells. At the onset of neural specification, embryonic stem cells (ESCs) upregulate CRB2, which then localizes apically in neural rosettes. Gain- and loss-of-function studies of CRB2 have shown that CRB2 is essential for the stabilization of other polarity proteins. Unlike CRB1, mutations in CRB2 do not appear to play a role in retinitis pigmentosa or in Leber congenital amaurosis.

Molekulargewicht: Predicted: 105, 129, and 141 kDa

Observed: 103, 128 kDa

Gen-ID: 286204

NCBI Accession: NP_775960

UniProt: Q5IJ48

Pathways: Notch Signalweg