CHCHD6 Antikörper (N-Term)

Produktnummer ABIN6991790

Der Kaninchen Polyklonal anti-CHCHD6 Antikörper wird verwendet zum Nachweis von CHCHD6 in Proben von Human. Er wurde validiert für WB und ELISA.

Kurzübersicht für CHCHD6 Antikörper (N-Term) (ABIN6991790)

Target: CHCHD6 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 6 (CHCHD6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHCHD6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-CHCHD6 Antikörper

Bindungsspezifität: AA 20-70, N-Term

Spezifität: CHCHD6 is predicted to not cross-react to other members of the CHCHD family.

Aufreinigung: CHCHD6 Antibody is affinity chromatography purified via peptide column.

Immunogen: Rabbit polyclonal CHCHD6 antibody was raised against a 17 amino acid peptide near the amino terminus of human CHCHD6. The immunogen is located within amino acids 20 - 70 of CHCHD6.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: CHCHD6 antibody can be used for detection of CHCHD6 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: CHCHD6 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: CHCHD6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu CHCHD6

Target: CHCHD6 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 6 (CHCHD6))

Andere Bezeichnung: CHCHD6

Hintergrund: CHCHD6 Antibody: CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain and has been observed in a complex with the mitochondrial proteins mitofilin, SAM50, metaxins 1 and 2, and CHCHD3. CHCHD6 knockdown causes severe defects in mitochondrial cristae morphology as well as reductions in cell growth, ATP production and oxygen consumption. This decrease of CHCHD6 also led to a reduction in mitofilin protein levels, while a knockdown of mitofilin resulted in a reduced level of CHCHD6, suggesting coordinate regulation between these two proteins. CHCHD6 knockdown in human cancer cells enhances their sensitivity to genotoxic anticancer drugs, suggesting that CHCHD6 may be a potential therapeutic anti-tumor target.

Molekulargewicht: Predicted: 26 kDa

Gen-ID: 84303

NCBI Accession: NP_115719

UniProt: Q9BRQ6