PLA1A Antikörper (C-Term)

Produktnummer ABIN6991764

Dieses Anti-PLA1A-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PLA1A in WB, ELISA und IF. Geeignet für Human und Ratte.

Kurzübersicht für PLA1A Antikörper (C-Term) (ABIN6991764)

Target: PLA1A (Phospholipase A1 Member A (PLA1A))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PLA1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-PLA1A Antikörper

Bindungsspezifität: AA 380-430, C-Term

Spezifität: At least three isoforms of PLA1A are known to exist, this antibody will detect all three isoforms.

Aufreinigung: PLA1A Antibody is affinity chromatography purified via peptide column.

Immunogen: PLA1A antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human PLA1A. The immunogen is located within amino acids 380 - 430 of PLA1A.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: PLA1A antibody can be used for detection of PLA1A by Western blot at 1 - 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PLA1A Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: PLA1A antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu PLA1A

Target: PLA1A (Phospholipase A1 Member A (PLA1A))

Andere Bezeichnung: PLA1A

Hintergrund: PLA1A Antibody: PLA1A is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine (PS) in liposomes and can also hydrolyze PS in apoptotic cells and activate platelets where the resulting 2-acyl-lysophosphatidylserine acts as a lipid mediator for mast cells, T cells, and neural cells, suggesting that a major function of PLA1A may be the production of lysophospholipid mediators. PLA1A is upregulated in rat peripheral blood cells bearing long-term surviving cardiac allograft. PLA1A is also expressed in human THP-1-derived macrophages and this expression is upregulated in cells treated with lipopolysaccharide, a TLR4 ligand. This upregulation is inhibited with corticosteroids, which are often used at high dosages to suppress chronic allograft rejection.

Molekulargewicht: 50 kDa

Gen-ID: 51365

NCBI Accession: NP_056984

UniProt: Q53H76