RGS22 Antikörper (N-Term)

Produktnummer ABIN6991738

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch RGS22 in ELISA, WB und IF. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für RGS22 Antikörper (N-Term) (ABIN6991738)

Target: RGS22 (Regulator of G-Protein Signaling 22 (RGS22))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RGS22 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-RGS22 Antikörper

Bindungsspezifität: AA 870-920, N-Term

Spezifität: At least four isoforms of RGS22 are known to exist, this antibody will detect the three longest isoforms. RGS22 antibody is predicted to not cross-react with other RGS proteins

Aufreinigung: RGS22 Antibody is affinity chromatography purified via peptide column.

Immunogen: RGS22 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human RGS22. The immunogen is located within amino acids 870 - 920 of RGS22.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: RGS22 antibody can be used for detection of RGS22 by Western blot at 1 - 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: RGS22 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: RGS22 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu RGS22

Target: RGS22 (Regulator of G-Protein Signaling 22 (RGS22))

Andere Bezeichnung: RGS22

Hintergrund: RGS22 Antibody: Regulator of G-protein signaling (RGS) proteins contain an 120 amino acid conserved domain, termed the RGS domain, that acts as a GTPase-activating protein that acts to reduce the signal transmitted by the receptor-activated G-alpha subunit. RGS22 is a recently identified member of this family that localizes to the testis and can interact with guanine nucleotide binding proteins alpha 11, 12, and 13 (GNA11, GNA12, and GNA13). While RGS22 has been postulated to play a role in spermiogenesis in the testis, it is also expressed in several cancer cell lines with an epithelial origin and associated with cancer metastasis. Its overexpression in a highly metastatic cancer causes a decrease in cell migration and a reduction of the invasive potential of the cells, suggesting that RGS22 may be a potential prognostic biomarker for metastasis.

Molekulargewicht: 139 kDa

Gen-ID: 26166

NCBI Accession: NP_056483

UniProt: Q8NE09

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling