TOX Antikörper (N-Term)

Produktnummer ABIN6991735

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch TOX in WB, ELISA und IF. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für TOX Antikörper (N-Term) (ABIN6991735)

Target: TOX (Thymus High Mobility Group Box Protein (TOX))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TOX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-TOX Antikörper

Bindungsspezifität: AA 130-180, N-Term

Spezifität: No alternatively spliced transcript variants have been observed.

Aufreinigung: TOX Antibody is affinity chromatography purified via peptide column.

Immunogen: TOX antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human TOX. The immunogen is located within amino acids 130 - 180 of TOX.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: TOX antibody can be used for detection of TOX by Western blot at 1 - 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: TOX Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: TOX antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu TOX

Target: TOX (Thymus High Mobility Group Box Protein (TOX))

Andere Bezeichnung: TOX

Hintergrund: TOX Antibody: TOX (thymocyte selection-associated high mobility group (HMG) box protein) is a member of the HMG box family of DNA-binding proteins and likely plays a role in the regulation of T-cell development. It is a 526 amino acid nuclear protein and the expression of TOX is upregulated by pre-T cell receptor (pre-TCR) and TCR activation in immature thymocytes. TOX-mediated positive selection is associated with up-regulation of RUNX3 and is calcineurin dependent. TOX-dependent transition to the CD4+CD8 stage is required for development of class II major histocompatibility complex-specific T cells.

Molekulargewicht: 58 kDa

Gen-ID: 9760

NCBI Accession: NP_055544

UniProt: O94900