DDX60 Antikörper (AA 1140-1190)

Produktnummer ABIN6991720

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch DDX60 in WB, ELISA und IF. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für DDX60 Antikörper (AA 1140-1190) (ABIN6991720)

Target: DDX60 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 60 (DDX60))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DDX60 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-DDX60 Antikörper

Bindungsspezifität: AA 1140-1190

Spezifität: At least three isoforms of DDX60 are known to exist, this antibody will detect all three isoforms.

Aufreinigung: DDX60 Antibody is affinity chromatography purified via peptide column.

Immunogen: DDX60 antibody was raised against a 17 amino acid synthetic peptide near the center of human DDX60. The immunogen is located within amino acids 1140 - 1190 of DDX60.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: DDX60 antibody can be used for detection of DDX60 by Western blot at 1 - 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: DDX60 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: DDX60 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu DDX60

Target: DDX60 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 60 (DDX60))

Andere Bezeichnung: DDX60

Hintergrund: DDX60 Antibody: DDX60 is a DEXD/H Box RNA helicase and the human homolog of the S. cerevisiae Ski2, a cofactor of RNA exosome. Expression of DDX60 increases after viral infection and binds to endogenous RIG-I, a cytoplasmic viral RNA sensor, as well as other RIG-I-like receptors such as MDA5 and LGP2. These proteins activate TBK1 and IKK-e, signaling IRF3 and NF-kB-responsive genes in the innate immune response pathway. DDX60 is required for the RIG-I- or MDA5-dependent response to viral infection, but is dispensable for TLR3-mediated signaling.

Molekulargewicht: Predicted: 125, 185, 188 kDa

Observed: 190 kDa

Gen-ID: 55601

NCBI Accession: NP_060101

UniProt: Q8IY21