CENPW Antikörper (N-Term)

Produktnummer ABIN6991719

Dieses Anti-CENPW-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CENPW in WB und ELISA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für CENPW Antikörper (N-Term) (ABIN6991719)

Target: CENPW (Centromere Protein W (CENPW))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CENPW Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-CENPW Antikörper

Bindungsspezifität: N-Term

Spezifität: At least three isoforms of CENPW are known to exist, this antibody will detect all three isoforms.

Aufreinigung: CENPW Antibody is affinity chromatography purified via peptide column.

Immunogen: CENPW antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human CENPW. The immunogen is located within the first 50 amino acids of CENPW.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: CENPW antibody can be used for detection of CENPW by Western blot at 0.5 - 1 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: CENPW Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: CENPW antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu CENPW

Target: CENPW (Centromere Protein W (CENPW))

Andere Bezeichnung: CENPW

Hintergrund: CENPW Antibody: CENPW was initially identified as a gene that was upregulated in multiple cancers, and whose overexpression in mouse fibroblast cells gave rise to distinct cancer-specific phenotypes. It was later found to be a nuclear protein that associated with CENPT, a component of CENPA nucleosome complex in the centromere, and is required for proper kinetochore function. CENPW also specifically interacts with the nucleolar phosphoprotein nucleophosmin, also known as B23 It has been suggested that nucleophosmin functions in the assembly of the kinetochore by interacting with CENPW during interphase. Overexpression of CENPW in the SKOV-3 human ovarian cancer cell line as well as in the zebrafish embryo led to apoptosis, suggesting that high levels of CENPW induces apoptotic cell death.

Gen-ID: 387103

NCBI Accession: NP_001012525

UniProt: Q5EE01