PHOX2B Antikörper (AA 130-180)

Produktnummer ABIN6991707

This anti-PHOX2B antibody (ABIN6991707) is a Rabbit Polyclonal antibody detecting PHOX2B in WB, ELISA. Suitable for Human, Mouse, Rat.

Kurzübersicht für PHOX2B Antikörper (AA 130-180) (ABIN6991707)

Target: PHOX2B (Paired-Like Homeobox 2b (PHOX2B))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PHOX2B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-PHOX2B Antikörper

Bindungsspezifität: AA 130-180

Spezifität: PHOX2B antibody is predicted to not cross-react with other paired homeobox family members.

Aufreinigung: PHOX2B Antibody is affinity chromatography purified via peptide column.

Immunogen: PHOX2B antibody was raised against a 15 amino acid synthetic peptide near the center of human PHOX2B. The immunogen is located within amino acids 130 - 180 of PHOX2B.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: PHOX2B antibody can be used for detection of PHOX2B by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PHOX2B Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: PHOX2B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu PHOX2B

Target: PHOX2B (Paired-Like Homeobox 2b (PHOX2B))

Andere Bezeichnung: PHOX2B

Hintergrund: PHOX2B Antibody: PHOX2A and PHOX2B (Paired mesoderm homeobox protein) are closely related, paired-homeodomain transcription factors that function as determinants of the noradrenergic phenotype during embryogenesis. PHOX2 proteins are crucial for the regulation of endogenous hydroxylases in neural crest cells and promote sympathetic neuron generation. Human PHOX2B contains one DNA binding homeobox domain and is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, PHOX2A controls only the differentiation of the main noradrenergic center of the brain. Regulation of PHOX2 may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons.

Gen-ID: 8929

NCBI Accession: NP_003915

UniProt: Q99453