TRIM21 Antikörper (AA 290-340)

Produktnummer ABIN6991636

Produktdetails anti-TRIM21 Antikörper

Target: TRIM21 (Tripartite Motif Containing 21 (TRIM21))

Bindungsspezifität: AA 290-340

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRIM21 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: TRIM21 antibody is human specific. This antibody is predicted to not cross-react with TRIM6.

Aufreinigung: TRIM21 antibody is affinity chromatography purified via peptide column.

Immunogen: Anti-TRIM21 antibody was raised against a peptide corresponding to 16 amino acids near the center of human TRIM21. The immunogen is located within amino acids 290-340 of TRIM21.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 0.5-2 μ,g/mL, IHC: 5 μ,g/mL, IF: 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples, Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: TRIM21 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: TRIM21 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu TRIM21

Target: TRIM21 (Tripartite Motif Containing 21 (TRIM21))

Andere Bezeichnung: TRIM21 (TRIM21 Produkte)

Synonyme: RNF81 antikoerper, RO52 antikoerper, SSA antikoerper, SSA1 antikoerper, Ro52 antikoerper, Ssa1 antikoerper, tripartite motif containing 21 antikoerper, tripartite motif-containing 21 antikoerper, TRIM21 antikoerper, Trim21 antikoerper

Hintergrund: TRIM21, a member of the tripartite motif (TRIM) family, is a part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus (1). RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus (2). TRIM21 also acts as a cytosolic antibody receptor, detection of intracellular antibodies activate immune signaling by stimulating the transcription factor pathways of NF-kappaB, AP-1, IRF3, IRF5, and IRF7, resulting in the production of proinflammatory cytokines and the induction of an antiviral state (3).

Molekulargewicht: Predicted: 54kD

Observed: 54 kD kDa

Gen-ID: 6737

NCBI Accession: NP_003132

UniProt: P19474