AFAP Antikörper (N-Term)

Produktnummer ABIN6991604

Der Kaninchen Polyklonal Anti-AFAP-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, AFAP in Proben von Human und Maus zu detektieren.

Kurzübersicht für AFAP Antikörper (N-Term) (ABIN6991604)

Target: AFAP (AFAP1) (Actin Filament Associated Protein 1 (AFAP1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AFAP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-AFAP Antikörper

Bindungsspezifität: AA 30-80, N-Term

Spezifität: Monomer and homomultimer of AFAP1 are known to exist, AFAP1 antibody is predicted to not cross-react with other AFAP family members.

Aufreinigung: AFAP1 Antibody is affinity chromatography purified via peptide column.

Immunogen: AFAP1 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human AFAP1. The immunogen is located within amino acids 30 - 80 of AFAP1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: AFAP1 antibody can be used for detection of AFAP1 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: AFAP1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: AFAP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu AFAP

Target: AFAP (AFAP1) (Actin Filament Associated Protein 1 (AFAP1))

Andere Bezeichnung: AFAP1

Hintergrund: AFAP1 Antibody: The actin filament-associated protein AFAP1 (AFAP-110) is an actin cross-linking protein first identified as a substrate of the viral oncogene v-Src. AFAP1 has a fundamental role in actin cytoskeleton arrangement. It contains a carboxyterminal actin-binding domain that directly binds to F-actin and serves as an adaptor protein in the regulation of SRC and PKC signal transduction by several functional domains, including 2 pleckstrin homology (PH) domains, a Src homology 3-binding (SH3-binding) motif, and several SH2-binding motifs. It is overexpressed in prostate carcinoma and contributes to tumor growth by regulating cell-matrix adhesions and migration in the cancer cells. AFAP1 represent a possible therapeutic target for controlling tumorigenesis and metastasis.

Gen-ID: 60312

NCBI Accession: NP_940997

UniProt: Q8N556