C2orf40 Antikörper (C-Term)

Produktnummer ABIN6991594

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch C2orf40 in WB, ELISA und ICC. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für C2orf40 Antikörper (C-Term) (ABIN6991594)

Target: C2orf40 (Chromosome 2 Open Reading Frame 40 (C2orf40))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C2orf40 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Produktdetails anti-C2orf40 Antikörper

Bindungsspezifität: C-Term

Spezifität: ECRG4 antibody is predicted to not cross-react with other ECRG family members.

Aufreinigung: ECRG4 Antibody is affinity chromatography purified via peptide column.

Immunogen: ECRG4 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human ECRG4. The immunogen is located within the last 50 amino acids of ECRG4.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ECRG4 antibody can be used for detection of ECRG4 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: ECRG4 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: ECRG4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu C2orf40

Target: C2orf40 (Chromosome 2 Open Reading Frame 40 (C2orf40))

Andere Bezeichnung: ECRG4

Hintergrund: ECRG4 Antibody: The esophageal cancer-related gene 4 (ECRG4), also known as Augurin, was identified through differential display screening between esophageal cancer and normal tissue. Hypermethylation of CpG sites in the ECRG4 promoter correlate with ECRG4 downregulation in numerous esophageal squamous cell carcinoma tissues.. In transfected cells, overexpression of ECRG4 induced G1 arrest, dephosphorylation of Rb and decreased expression of cyclins D1 and D3. Increased expression of ECRG4 in aged mouse brain is observed compared with young mouse brain. The increased ECRG4 level was accompanied by elevated senescence-associated acidic beta-galactosidase activity, suggesting that ECRG4 is involved in cellular differentiation and senescence.

Gen-ID: 84417

UniProt: Q9H1Z8