CCDC141 Antikörper (N-Term)

Produktnummer ABIN6991553

Der Kaninchen Polyklonal anti-CCDC141 Antikörper wird verwendet zum Nachweis von CCDC141 in Proben von Human und Maus. Er wurde validiert für WB, ELISA, IF und IHC (p).

Kurzübersicht für CCDC141 Antikörper (N-Term) (ABIN6991553)

Target: CCDC141 (Coiled-Coil Domain Containing 141 (CCDC141))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CCDC141 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-CCDC141 Antikörper

Bindungsspezifität: AA 40-90, N-Term

Spezifität: At least four isoforms of CCDC141 are known to exist.

Aufreinigung: CCDC141 Antibody is affinity chromatography purified via peptide column.

Immunogen: CCDC141 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CCDC141. The immunogen is located within amino acids 40 - 90 of CCDC141.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: CCDC141 antibody can be used for detection of CCDC141 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: CCDC141 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: CCDC141 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu CCDC141

Target: CCDC141 (Coiled-Coil Domain Containing 141 (CCDC141))

Andere Bezeichnung: CCDC141

Hintergrund: CCDC141 Antibody: Coiled-coil domain-containing protein 141 (CCDC141), also known as CAMDI, is a recently identified disrupted in schizophrenia 1 (DISC1)-binding protein that also associates with myosin II. CCDC141 preferentially associates with phosphomyosin II and causes an accumulation of phosphomyosin II at the centrosome in a DISC1-dependent manner. Knockdown of CCDC141 expression by RNAi led to severely impaired radial migration with disoriented chromosomes, suggesting that CCDC141 is required for radial migration through DISC1 and myosin II-mediated centrosome positioning during neuronal development.

Gen-ID: 285025

NCBI Accession: NP_775919

UniProt: Q6ZP82