VASH1 Antikörper (C-Term)

Produktnummer ABIN6991536

Dieses Anti-VASH1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von VASH1 in WB, ELISA, IF und IHC (p). Geeignet für Human, Maus und Ratte.

Kurzübersicht für VASH1 Antikörper (C-Term) (ABIN6991536)

Target: VASH1 (Vasohibin 1 (VASH1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VASH1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-VASH1 Antikörper

Bindungsspezifität: AA 290-340, C-Term

Spezifität: VASH1 antibody is predicted to not cross-react with other vasohibin protein family members. At least two isoforms are known to exist, this antibody will recognize only the long isoform.

Aufreinigung: VASH1 Antibody is affinity chromatography purified via peptide column.

Immunogen: VASH1 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human VASH1. The immunogen is located within amino acids 290 - 340 of VASH1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: VASH1 antibody can be used for detection of VASH1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: VASH1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: VASH1 antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu VASH1

Target: VASH1 (Vasohibin 1 (VASH1))

Andere Bezeichnung: VASH1

Hintergrund: VASH1 Antibody: VASH1 was originally identified as an endothelium-derived vascular endothelial growth factor (VEGF)-inducible angiogenesis inhibitor that acts in a negative feedback manner. VASH1 mRNA is expressed brain, heart, kidney and placenta in the adult, with robust expression in various organs during embryonic development. VASH1 expression in tumor cells and tumor vasculature is silenced by methylation by increased expression of Zeste homolog 2 (EZH2). The increase of EZH2 expression is induced by VEGF stimulation, leading to poor clinical prognosis. Recombinant adenovirus expressing VASH prevented tumor angiogenesis and inhibited tumor growth, suggesting that it may be a potentially valuable antitumor therapy in the clinic.

Gen-ID: 22846

NCBI Accession: NP_055724

UniProt: Q7L8A9