SIK1 Antikörper (AA 340-390)

Produktnummer ABIN6991527

Dieses Anti-SIK1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SIK1 in WB, ELISA und IHC (p). Geeignet für Human.

Kurzübersicht für SIK1 Antikörper (AA 340-390) (ABIN6991527)

Target: SIK1 (Salt-Inducible Kinase 1 (SIK1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-SIK1 Antikörper

Bindungsspezifität: AA 340-390

Spezifität: Two isoforms of SIK1 are known to exist, this antibody will detect both isoforms. SIK1 antibody is predicted to not cross-react with other SIK protein family members.

Aufreinigung: SIK1 Antibody is affinity chromatography purified via peptide column.

Immunogen: SIK1 antibody was raised against an 18 amino acid synthetic peptide near the center of human SIK1. The immunogen is located within amino acids 340 - 390 of SIK1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: SIK1 antibody can be used for detection of SIK1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: SIK1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: SIK1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu SIK1

Target: SIK1 (Salt-Inducible Kinase 1 (SIK1))

Andere Bezeichnung: SIK1

Hintergrund: SIK1 Antibody: Salt-inducible kinase 1 (SIK1), also known as SNF1LK or MSK, plays a role in histone modification and G2/M cell cycle regulation. It is a 783 amino acid protein that contains one UBA domain and belongs to the Ser/Thr protein kinase family (AMPK subfamily). Localized to both the nucleus and the cytoplasm, SIK1 is a class II HDAC kinase that uses magnesium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins and is thought to be important for the early stages of skeletal muscle growth and myocardial cell differentiation.

Gen-ID: 150094

NCBI Accession: NP_775490

UniProt: P57059

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process