N4BP1 Antikörper (N-Term)

Produktnummer ABIN6991485

Produktdetails anti-N4BP1 Antikörper

Target: N4BP1 (NEDD4 Binding Protein 1 (N4BP1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser N4BP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: At least three isoforms of N4BP1 are known to exist, this antibody will only detect the longest isoform.

Aufreinigung: N4BP1 Antibody is affinity chromatography purified via peptide column.

Immunogen: N4BP1 antibody was raised against a 18 amino acid synthetic peptide near the amino terminus of human N4BP1. The immunogen is located within the first 50 amino acids of N4BP1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: N4BP1 antibody can be used for detection of N4BP1 by Western blot at 0.5 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: N4BP1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: N4BP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu N4BP1

Target: N4BP1 (NEDD4 Binding Protein 1 (N4BP1))

Andere Bezeichnung: N4BP1 (N4BP1 Produkte)

Synonyme: AI481586 antikoerper, C81621 antikoerper, RGD1305179 antikoerper, wu:fi03b05 antikoerper, zgc:66437 antikoerper, NEDD4 binding protein 1 antikoerper, Nedd4 binding protein 1 antikoerper, nedd4 binding protein 1 antikoerper, nedd4 binding protein 1 L homeolog antikoerper, N4BP1 antikoerper, N4bp1 antikoerper, n4bp1 antikoerper, n4bp1.L antikoerper

Hintergrund: N4BP1 Antibody: Nedd4-binding partner-1 (N4BP1) is a developmentally expressed protein interactor and monoubiquitylation substrate of Nedd4, a HECT domain-containing ubiquitin ligase that mediates ubiquitylation and proteasome degradation of target proteins and may have a fundamental role to play in embryonic processes. N4BP1 can undergo Nedd4-mediated polyubiquitylation and proteosomal degradation. N4BP1 also functions as a negative regulator of AIF4 (also known as ITCH or Atrophin-1), an E3-ubiquitin ligase, by interacting with the second WW domain of AIF4 and impairing ubiquitination of substrates.

Gen-ID: 9683

NCBI Accession: NP_694574

UniProt: O75113