BANP Antikörper (AA 300-350)

Produktnummer ABIN6991411

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch BANP in WB, ELISA, IF und IHC (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für BANP Antikörper (AA 300-350) (ABIN6991411)

Target: BANP (Protein BANP (BANP))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BANP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-BANP Antikörper

Bindungsspezifität: AA 300-350

Aufreinigung: BANP Antibody is affinity chromatography purified via peptide column.

Immunogen: BANP antibody was raised against a 14 amino acid synthetic peptide near the center of human BANP. The immunogen is located within amino acids 300 - 350 of BANP.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: BANP antibody can be used for detection of BANP by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: BANP Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: BANP antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu BANP

Target: BANP (Protein BANP (BANP))

Andere Bezeichnung: BANP

Hintergrund: BANP Antibody: BANP was initially identified as a binding protein to BTG3 in a yeast two-hybrid screen. BANP acts as a tumor suppressor by stabilizing p53 expression and leading to cell cycle arrest. p53 in turn binds to upstream elements of the BANP promoter, thereby forming a feedback loop. BANP is down-regulated in advanced stages of human breast cancer, and its overexpression in breast cancer cell lines inhibits their ability to metastasize by modulating TGF-beta signaling. Furthermore, BANP can modulate NF-κ,B transactivation and can inhibit tumorigenesis by regulating NF-κ,B target genes. Recent experiments have shown that BANP can also repress HIV-1 LTR mediated transcription by tethering the LTR matrix attachment region to nuclear matrix.

Gen-ID: 54971

NCBI Accession: NP_001167014

UniProt: Q8N9N5