SCUBE3 Antikörper (AA 440-490)

Produktnummer ABIN6991375

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SCUBE3 in ELISA und IHC (p). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für SCUBE3 Antikörper (AA 440-490) (ABIN6991375)

Target: SCUBE3 (Signal Peptide, CUB Domain, EGF-Like 3 (SCUBE3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SCUBE3 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-SCUBE3 Antikörper

Bindungsspezifität: AA 440-490

Aufreinigung: SCUBE3 Antibody is affinity chromatography purified via peptide column.

Immunogen: SCUBE3 antibody was raised against a 15 amino acid peptide near the center of human SCUBE3. The immunogen is located within amino acids 440 - 490 of SCUBE3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: SCUBE3 antibody can be used for detection of SCUBE3 by immunohistochemistry at 5 μ,g/mL.

Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: SCUBE3 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: SCUBE3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu SCUBE3

Target: SCUBE3 (Signal Peptide, CUB Domain, EGF-Like 3 (SCUBE3))

Andere Bezeichnung: SCUBE3

Hintergrund: SCUBE3 Antibody: SCUBE3 is a member of a family of secreted glycoproteins that contain N-terminal EGF-like repeats and C-terminal cysteine-rich motifs and CUB domain and is highly expressed in primary osteoblasts and bones, and to a lesser extent in heart (1,2). Other studies have shown that overexpression of SCUBE3 in mice induced cardiac hypertrophy, suggesting that it may also play a role in the regulation of cardiac growth. SCUBE3 has been shown to be an endogenous TGF-beta receptor ligand (3,4) and is thought to promote lung cancer cell mobility and invasiveness. In lung cancer cells, the secreted SCUBE3 protein was cleaved by MMP2 and MMP9, allowing the activation of the TGF-beta receptor, the increase of Smad2/3 transcriptional activity and the upregulation of expression of proteins such as TGF-beta1, VEGF, Snail, and Slug.

Molekulargewicht: Predicted: 109 kDa

Gen-ID: 222663

NCBI Accession: NP_689966

UniProt: Q8IX30