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RNF8 Antikörper (C-Term)

RNF8 Reaktivität: Human, Maus, Ratte WB, ELISA, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6991342
  • Target Alle RNF8 Antikörper anzeigen
    RNF8 (Ring Finger Protein 8 (RNF8))
    Bindungsspezifität
    • 8
    • 8
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    AA 330-380, C-Term
    Reaktivität
    • 51
    • 26
    • 18
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 45
    • 4
    • 1
    • 1
    Kaninchen
    Klonalität
    • 50
    • 1
    Polyklonal
    Konjugat
    • 22
    • 4
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser RNF8 Antikörper ist unkonjugiert
    Applikation
    • 51
    • 20
    • 13
    • 8
    • 5
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF)
    Spezifität
    At least three isoforms of RNF8 are known to exist, this antibody will detect all three isoforms.
    Aufreinigung
    RNF8 Antibody is affinity chromatography purified via peptide column.
    Immunogen
    RNF8 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human RNF8. The immunogen is located within amino acids 330 - 380 of RNF8.
    Isotyp
    IgG
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  • Applikationshinweise
    RNF8 antibody can be used for detection of RNF8 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunoflourescence starting at 20 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in human samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    RNF8 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,4 °C
    Informationen zur Lagerung
    RNF8 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    RNF8 (Ring Finger Protein 8 (RNF8))
    Andere Bezeichnung
    RNF8 (RNF8 Produkte)
    Synonyme
    hRNF8 antikoerper, 3830404E21Rik antikoerper, AIP37 antikoerper, RNF8 antikoerper, rnf8 antikoerper, fc66f09 antikoerper, wu:fc66f09 antikoerper, zgc:55936 antikoerper, zgc:77313 antikoerper, ring finger protein 8 antikoerper, ring finger protein 8, E3 ubiquitin protein ligase S homeolog antikoerper, ring finger protein 8, E3 ubiquitin protein ligase L homeolog antikoerper, ring finger protein 8, E3 ubiquitin protein ligase antikoerper, RNF8 antikoerper, Rnf8 antikoerper, rnf8.S antikoerper, rnf8.L antikoerper, rnf8 antikoerper
    Hintergrund
    RNF8 Antibody: RNF8 was identified as a ubiquitin ligase (E3) containing a RING finger motif and a FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes including UBE2E1/UBCH6, UBE2E2, and UBE2E3. RNF8 assembles at DNA double-strand breaks (DSBs) via interactions though the FHA domain with the adaptor protein MDC1, resulting in an increase in DSB-associated H2A histone ubiquitinations mediated by the associated ubiquitin ligase RNF168 followed by the accumulation of 53BP1 and BRCA1 repair proteins. Together with RNF168, RNF8 plays an integral part of class switch recombination in B cells, allowing the production of several classes of antibodies, through the recruitment of 53BP1 and BRCA1 to the DSB sites.
    Molekulargewicht
    Predicted: 46, 53 kDa

    Observed: 50 kDa
    Gen-ID
    9025
    NCBI Accession
    NP_003949
    UniProt
    O76064
    Pathways
    Production of Molecular Mediator of Immune Response
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